علي حيدر حمزة علوش

EXPERIENCE Al Yarmouk Teaching Hospital (Ministry of Health, Baghdad, Iraq, March 2009- March 2010). Pharmacist under training. Management of medicine supply and health equipment to different hospital departments. Work in concert with physicians to administer safe drug therapy regimens. Ministry of health representative to fulfill the hospital needs of medicines from the private sector. Seminar presenting and weekly report of newly admitted cases at the hospital. The University of Baghdad, College of Pharmacy (Ministry of Higher Education and Scientific Research, Baghdad, Iraq, March 2010- August 2018). Laboratory instructor in the clinical pharmacy department (March 2010- March 2011). Teaching students in the final fifth year how to conduct the patient health information. Preparing and managing exams and quizzes in clinical pharmacy courses and ethics. Laboratory instructor in the pharmaceutical chemistry department (March 2011- July 2014). Laboratory and chemicals inventory and design for undergraduate students’ organic and inorganic chemistry experiments in safety protocol procedures. Monitoring students’ progress in performing their experiment independently with the growing ability to identify unknown chemicals by following specific guidelines. Licensed pharmacist (Iraq, 2012-present). Visiting lecturer Al Yarmouk College, Pharmacy Department (Iraq, Baghdad, 2011-2012). Al Israa College, Pharmacy Department (Iraq, Baghdad, Fall 2013). Al Rafedien College, Pharmacy Department (Iraq, Baghdad, 2017-2018). Teaching assistant, The University of Toledo, Toledo, Ohio, Aug 2015-present. MBC 3310 Medicinal Chemistry I: Drug Action and Design (Fall 2015, 2016). MBC 3880 Medicinal and the Biological Chemistry Laboratory (Fall 2019, 2020). MBC 3860 Microbiology for Pharmaceutical Professionals (Spring 2019, 2020, 2021, 2023). MBC 3552 Physiological Chemistry II Cellular Metabolism and Homeostasis (Spring 2021, 2022, 2023). Design the experiments and set up the lab for the active learning synthesis section. Grading of lecture homework. Proctoring midterms and final exams.

PROJECTS Design, Synthesis, and biological evaluation of PF543 Analogs as Two Pore Channel Blockers. More than 100 compounds were synthesized by introducing different steric and electronic chemical groups. Extensive structural-activity relationship studies were collected from the synthesized compounds.  The purity standard of the final compound was achieved by complete NMR and mass characterization along with HPLC analysis. Sea urchin egg homogenate was used as a golden standard to evaluate the inhibitory action of PF543 analogs to block NAADP- Calcium mediated release through the two-pore channel. DO.11.10 cells were used as another biological assay to explore the most potent compounds. Off-target activity, such as Sphingosine kinase II inhibition, was also studied using a human sphingosine kinase kit. Synthesis of 2’- Hydroxymethyl Cytidine as a Potential Inhibitor for Hepatitis C Virus Polymerase Enzyme. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1470333250. (Master thesis 2016). 2’-Modified nucleoside was successfully synthesized with complete characterization to work as a chain terminator targeting NS5P HCV polymerase enzyme. Docking program was helped and guided to develop other sets of Sofosbuvir analogs as potent antiviral agents. Repeat with modified synthetic procedures, synthesis of 5’-Pseudouridine radical precursors as a research tool to study the oxidative RNA damages. Developed and design new productive procedures to synthesize the fully protected Pseudouridine on the gram scale starting from protected ribose. Synthesis of cyclic-di-GMP as an essential component in some gram-negative biofilm components.